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Testing a new immunotherapy treatment for neuroblastoma

T cell

Immunotherapies are changing the outlook for many cancer patients.

Drugs that block cancer cells from deflecting an immune attack are now routinely used to treat advanced skin and kidney cancers, and are showing promise in other types of cancer too.

But cancers are complex and diverse – what works well against one type of cancer might have little effect against another. The immunotherapies available for some patients aren’t a magic bullet that will work for everyone.   

So researchers all over the world are looking into other potential treatments that unleash the immune system against cancer, and one of these approaches uses genetic engineering to modify our immune cells.

Professor John Anderson, a doctor and researcher who specialises in children’s cancers, tells us more about a Cancer Research UK clinical trial that he’s the leading doctor for.

It’s an early stage clinical trial that we’re running at Great Ormond Street Hospital and University College Hospital, testing the potential of a new type of immunotherapy to treat neuroblastoma – an aggressive type of cancer that most commonly occurs in young children.

What is the new treatment, and how does it work?

The treatment is based on genetically engineering a type of white blood cell in our immune system, called a T cell, to turn it into a cancer-killing cell.

The normal role of T cells is to protect us from infections, particularly viruses. Killer T cells can spot cells that are infected with a dangerous virus and destroy them, wiping out the infection. They can also spot cells that are damaged or faulty, and destroy them too.

Nearly all of our cells display small fragments of their contents on their surface as part of routine health checks. T cells wander through your body, using specialised scanners – called T cell receptors – to examine the fragments on cells as they pass by.

T cells are trained not to react to healthy cells. But when a cell is infected or damaged it usually causes changes to the fragments the cell displays, and these unusual fragments set off an alarm in T cells.

The immune system is very powerful so there are lots of checks and balances in place. But if T cells receive enough danger signals, they begin to multiply, attack and destroy the damaged or infected cells.

It’s the T cell attack that forms the basis of the treatment we’re testing. We’re using genetic engineering to create designer T cells that focus the T cells’ attack on the cancer cells. These engineered cells are called Chimeric Antigen Receptor T cells (CAR T cells).

The biggest challenge is finding a target to train the T cells to hunt, and there are two problems to tackle. Firstly, some cancers are very diverse, which means there are few, if any, targets that all the cancer cells share.

Secondly, the fragments on the surface of cancer cells are often very similar to those displayed by the same type of healthy cell, meaning that the T cells might attack healthy tissues as well, potentially causing side effects.

But in the case of neuroblastoma, there is a good target. Levels of a molecule called GD2 are high on most neuroblastoma cells, and it’s not found on most healthy cells. So that’s what we engineer the CAR T cells to target.

How do you genetically engineer someone’s T cells?

The process starts by taking blood from a patient – either normally from a vein, or using a machine that only takes out the white blood cells.

In specialised labs, we stimulate the patient’s T cells to start multiplying, then we use an engineered virus to smuggle new genes into the T cell. One of these genes contains the instructions for the T cells to make the targeting molecule (CAR) that recognises GD2.

We grow the modified CAR T cells for a few days in the lab, freeze them in batches, test them for cancer killing ability, then give them back to the patient through an IV drip.

Who can join the trial?

This is the first time we’ve tested this treatment in patients, so our first priority is measuring safety.

The immune system is extremely powerful, so any immunotherapy has the potential to cause serious side effects, and in the most severe cases, can be fatal.

This is a phase I trial and our goal is to find out the new therapy’s safety, and what doses we can give it to children without causing severe side effects.

Because we don’t know yet if it will be effective, we’re testing the CAR T cells in children who have run out treatment options. These are poorly children, whose neuroblastoma has come back and no longer responds to chemotherapy.

The trial will only include a small number of children at this stage. We predict in the range of 15 to 20 children.

The trial starts by simply giving the CAR T cells to the patient. If there are no bad reactions, then the next patients receive increasing doses of chemotherapy before giving them the CAR T cells. This will reduce the numbers of competing normal T cells and T cells that naturally dampen down immune reactions, giving the CAR T cells a better chance of surviving and mounting an attack on the cancer cells.

We’ll be monitoring the children very closely for side effects and to control the immune reaction if it gets out of hand.

Will this treatment be a big breakthrough for children with neuroblastoma?

We simply don’t know yet. That’s what we’re trying to determine through clinical trials.

Like any new treatment, the CAR T cells need to go through a rigorous process of testing. This first phase is to find out if they’re safe and what dose to use them at. We will also get some information on whether the CAR T cells start attacking the neuroblastoma cells, as they’re designed to do.

If all goes well, then we can take the treatment into larger clinical trials to start working out how effective it is.

CAR T cells have been showing lots of promise in clinical trials testing them in people with blood cancers, including various types of leukaemia and lymphoma, with many patients going into complete remission.

But their deployment against solid tumours in adult cancers has had mixed success.

And there are still safety concerns associated with CAR T cells. Once they have been unleashed, it’s hard to stop them, and an out of control immune reaction can cause death.

So we need to proceed with caution and make sure safety is at the top of our agenda. At the same time, the outlook for children with neuroblastoma that’s not responded to treatment rarely survive for more than 2 years and we urgently need better treatments for these children.

Could CAR T cells be part of the answer? Only time will tell.

Interviewed by Emma Smith



from Cancer Research UK – Science blog http://ift.tt/2qx2eJE
T cell

Immunotherapies are changing the outlook for many cancer patients.

Drugs that block cancer cells from deflecting an immune attack are now routinely used to treat advanced skin and kidney cancers, and are showing promise in other types of cancer too.

But cancers are complex and diverse – what works well against one type of cancer might have little effect against another. The immunotherapies available for some patients aren’t a magic bullet that will work for everyone.   

So researchers all over the world are looking into other potential treatments that unleash the immune system against cancer, and one of these approaches uses genetic engineering to modify our immune cells.

Professor John Anderson, a doctor and researcher who specialises in children’s cancers, tells us more about a Cancer Research UK clinical trial that he’s the leading doctor for.

It’s an early stage clinical trial that we’re running at Great Ormond Street Hospital and University College Hospital, testing the potential of a new type of immunotherapy to treat neuroblastoma – an aggressive type of cancer that most commonly occurs in young children.

What is the new treatment, and how does it work?

The treatment is based on genetically engineering a type of white blood cell in our immune system, called a T cell, to turn it into a cancer-killing cell.

The normal role of T cells is to protect us from infections, particularly viruses. Killer T cells can spot cells that are infected with a dangerous virus and destroy them, wiping out the infection. They can also spot cells that are damaged or faulty, and destroy them too.

Nearly all of our cells display small fragments of their contents on their surface as part of routine health checks. T cells wander through your body, using specialised scanners – called T cell receptors – to examine the fragments on cells as they pass by.

T cells are trained not to react to healthy cells. But when a cell is infected or damaged it usually causes changes to the fragments the cell displays, and these unusual fragments set off an alarm in T cells.

The immune system is very powerful so there are lots of checks and balances in place. But if T cells receive enough danger signals, they begin to multiply, attack and destroy the damaged or infected cells.

It’s the T cell attack that forms the basis of the treatment we’re testing. We’re using genetic engineering to create designer T cells that focus the T cells’ attack on the cancer cells. These engineered cells are called Chimeric Antigen Receptor T cells (CAR T cells).

The biggest challenge is finding a target to train the T cells to hunt, and there are two problems to tackle. Firstly, some cancers are very diverse, which means there are few, if any, targets that all the cancer cells share.

Secondly, the fragments on the surface of cancer cells are often very similar to those displayed by the same type of healthy cell, meaning that the T cells might attack healthy tissues as well, potentially causing side effects.

But in the case of neuroblastoma, there is a good target. Levels of a molecule called GD2 are high on most neuroblastoma cells, and it’s not found on most healthy cells. So that’s what we engineer the CAR T cells to target.

How do you genetically engineer someone’s T cells?

The process starts by taking blood from a patient – either normally from a vein, or using a machine that only takes out the white blood cells.

In specialised labs, we stimulate the patient’s T cells to start multiplying, then we use an engineered virus to smuggle new genes into the T cell. One of these genes contains the instructions for the T cells to make the targeting molecule (CAR) that recognises GD2.

We grow the modified CAR T cells for a few days in the lab, freeze them in batches, test them for cancer killing ability, then give them back to the patient through an IV drip.

Who can join the trial?

This is the first time we’ve tested this treatment in patients, so our first priority is measuring safety.

The immune system is extremely powerful, so any immunotherapy has the potential to cause serious side effects, and in the most severe cases, can be fatal.

This is a phase I trial and our goal is to find out the new therapy’s safety, and what doses we can give it to children without causing severe side effects.

Because we don’t know yet if it will be effective, we’re testing the CAR T cells in children who have run out treatment options. These are poorly children, whose neuroblastoma has come back and no longer responds to chemotherapy.

The trial will only include a small number of children at this stage. We predict in the range of 15 to 20 children.

The trial starts by simply giving the CAR T cells to the patient. If there are no bad reactions, then the next patients receive increasing doses of chemotherapy before giving them the CAR T cells. This will reduce the numbers of competing normal T cells and T cells that naturally dampen down immune reactions, giving the CAR T cells a better chance of surviving and mounting an attack on the cancer cells.

We’ll be monitoring the children very closely for side effects and to control the immune reaction if it gets out of hand.

Will this treatment be a big breakthrough for children with neuroblastoma?

We simply don’t know yet. That’s what we’re trying to determine through clinical trials.

Like any new treatment, the CAR T cells need to go through a rigorous process of testing. This first phase is to find out if they’re safe and what dose to use them at. We will also get some information on whether the CAR T cells start attacking the neuroblastoma cells, as they’re designed to do.

If all goes well, then we can take the treatment into larger clinical trials to start working out how effective it is.

CAR T cells have been showing lots of promise in clinical trials testing them in people with blood cancers, including various types of leukaemia and lymphoma, with many patients going into complete remission.

But their deployment against solid tumours in adult cancers has had mixed success.

And there are still safety concerns associated with CAR T cells. Once they have been unleashed, it’s hard to stop them, and an out of control immune reaction can cause death.

So we need to proceed with caution and make sure safety is at the top of our agenda. At the same time, the outlook for children with neuroblastoma that’s not responded to treatment rarely survive for more than 2 years and we urgently need better treatments for these children.

Could CAR T cells be part of the answer? Only time will tell.

Interviewed by Emma Smith



from Cancer Research UK – Science blog http://ift.tt/2qx2eJE

Moon and Regulus on May 3 and 4

Our annual fund-raiser ends May 5. EarthSky needs your help to keep going! Please donate!

Want to donate via PayPal or send a check to EarthSky? Click here.

Tonight – May 3, 2017 – and tomorrow night, look outside for the moon and find the star Regulus nearby. Regulus is the brightest star in the constellation Leo the Lion. As seen from North America and much of the world, the moon will appear to the west of Regulus on the night of May 3, and then to the east of Regulus on the nights of May 4 and May 5.

That much-brighter point of light to the east of the moon and Regulus is the king planet Jupiter, brightest starlike object in the evening sky. From most places worldwide, the waxing gibbous moon will pair up most closely with Jupiter on the evening of May 7.

Our friends in Australia and New Zealand can watch the moon occult (pass in front of) Regulus on the evening of May 4, 2017. Regulus will disappear behind the dark side of the moon and reappear on the moon’s illuminated side. The occultation starts at or near sunset on the Australian west coast but after nightfall at more easterly Australian locations. For your convenience, we give the occultation times in local time for Perth (Western Australia) and Sydney (New South Wales):

Perth, Western Australia
Occultation begins: 5:15 p.m. AWST
Occultation ends: 6:01 p.m. AWST

Sydney, New South Wales
Occultation begins: 9:14 p.m. AEST
Occultation ends: 10:35 p.m. AEST

Occultation chart via IOTA. Everyplace in between the solid white lines sees the occultation in a nighttime sky. Everywhere between the dotted red lines has the occultation taking place in a daytime sky, and the short blue lines indicate where the occultation occurs at dusk. Click here to find out occultation times in Universal Time.

Want more information? Click here to find out the occultation times for numerous localities in Australia and new Zealand in Universal Time. Remember that you must convert from Universal Time to your local time. Here’s how.

Tonight’s moonlit glare might make it hard to see that Regulus dots the bottom of a backwards question mark pattern of stars. This pattern is known as The Sickle, and it outlines the Lion’s head and mane. Regulus, meanwhile, is often called the Lion’s Heart.

The name for Leo’s second brightest star, Denebola, comes from an Arabic term which translates to the Lion’s Tail. Two other stars – Zosma and Chertan – form a noticeable triangle with Denebola to draw out the hindquarters and tail of Leo the Lion. (See the chart of Leo the Lion below.)

The waxing moon will make it difficult to envision the celestial Lion this upcoming week. However, if you can locate the star Regulus, you can view the Lion in all his starlit majesty during the upcoming moon-free evenings in the last week week of May and the first week of June.

A planisphere is virtually indispensable tool for beginning stargazers. Order your EarthSky planisphere from our store.

The Big Dipper bowl stars Megrez and Phecda serve as your faithful pointer stars to Regulus, the heart star of Leo the Lion.

The Big Dipper bowl stars Megrez and Phecda serve as your faithful pointer stars to Regulus, the Heart of the Lion in the constellation Leo.

Image via Wikimedia Commons

Are you familiar with the Big Dipper? If so, this star formation serves as a wonderful guide to the Leo star Regulus.

From mid-northern latitudes, the upside-down Big Dipper shines way up high in the northern sky as darkness falls. The Big Dipper is even visible from the southern tropics, though it sits lower down in their northern sky on these May and June evenings.

Draw an imaginary line from the star Megrez and through the star Phecda, and then take a long jump to the star Regulus. Try this star-hopping trick tonight. Then try it again when the moon leaves the evening sky in another couple weeks.

Bottom line: On the night of May 3, 2017, the bright star near the moon is Regulus, the brightest star in the constellation Leo the Lion, often called the Lion’s Heart.

Enjoying EarthSky so far? Sign up for our free daily newsletter today!

Donate: Your support means the world to us



from EarthSky http://ift.tt/1SIZl2c

Our annual fund-raiser ends May 5. EarthSky needs your help to keep going! Please donate!

Want to donate via PayPal or send a check to EarthSky? Click here.

Tonight – May 3, 2017 – and tomorrow night, look outside for the moon and find the star Regulus nearby. Regulus is the brightest star in the constellation Leo the Lion. As seen from North America and much of the world, the moon will appear to the west of Regulus on the night of May 3, and then to the east of Regulus on the nights of May 4 and May 5.

That much-brighter point of light to the east of the moon and Regulus is the king planet Jupiter, brightest starlike object in the evening sky. From most places worldwide, the waxing gibbous moon will pair up most closely with Jupiter on the evening of May 7.

Our friends in Australia and New Zealand can watch the moon occult (pass in front of) Regulus on the evening of May 4, 2017. Regulus will disappear behind the dark side of the moon and reappear on the moon’s illuminated side. The occultation starts at or near sunset on the Australian west coast but after nightfall at more easterly Australian locations. For your convenience, we give the occultation times in local time for Perth (Western Australia) and Sydney (New South Wales):

Perth, Western Australia
Occultation begins: 5:15 p.m. AWST
Occultation ends: 6:01 p.m. AWST

Sydney, New South Wales
Occultation begins: 9:14 p.m. AEST
Occultation ends: 10:35 p.m. AEST

Occultation chart via IOTA. Everyplace in between the solid white lines sees the occultation in a nighttime sky. Everywhere between the dotted red lines has the occultation taking place in a daytime sky, and the short blue lines indicate where the occultation occurs at dusk. Click here to find out occultation times in Universal Time.

Want more information? Click here to find out the occultation times for numerous localities in Australia and new Zealand in Universal Time. Remember that you must convert from Universal Time to your local time. Here’s how.

Tonight’s moonlit glare might make it hard to see that Regulus dots the bottom of a backwards question mark pattern of stars. This pattern is known as The Sickle, and it outlines the Lion’s head and mane. Regulus, meanwhile, is often called the Lion’s Heart.

The name for Leo’s second brightest star, Denebola, comes from an Arabic term which translates to the Lion’s Tail. Two other stars – Zosma and Chertan – form a noticeable triangle with Denebola to draw out the hindquarters and tail of Leo the Lion. (See the chart of Leo the Lion below.)

The waxing moon will make it difficult to envision the celestial Lion this upcoming week. However, if you can locate the star Regulus, you can view the Lion in all his starlit majesty during the upcoming moon-free evenings in the last week week of May and the first week of June.

A planisphere is virtually indispensable tool for beginning stargazers. Order your EarthSky planisphere from our store.

The Big Dipper bowl stars Megrez and Phecda serve as your faithful pointer stars to Regulus, the heart star of Leo the Lion.

The Big Dipper bowl stars Megrez and Phecda serve as your faithful pointer stars to Regulus, the Heart of the Lion in the constellation Leo.

Image via Wikimedia Commons

Are you familiar with the Big Dipper? If so, this star formation serves as a wonderful guide to the Leo star Regulus.

From mid-northern latitudes, the upside-down Big Dipper shines way up high in the northern sky as darkness falls. The Big Dipper is even visible from the southern tropics, though it sits lower down in their northern sky on these May and June evenings.

Draw an imaginary line from the star Megrez and through the star Phecda, and then take a long jump to the star Regulus. Try this star-hopping trick tonight. Then try it again when the moon leaves the evening sky in another couple weeks.

Bottom line: On the night of May 3, 2017, the bright star near the moon is Regulus, the brightest star in the constellation Leo the Lion, often called the Lion’s Heart.

Enjoying EarthSky so far? Sign up for our free daily newsletter today!

Donate: Your support means the world to us



from EarthSky http://ift.tt/1SIZl2c

About that 130,000 Human Occupation in California [Greg Laden's Blog]

A claim is being made, in a recent issue of Nature Magazine, that humans were active in the vicinity of San Diego well over 100,000 years before archaeologists think humans were even in the New World. Most commentary on this claim dismisses it out of hand, but out of hand rejections are no better than foundationless assertions. Let’s take a closer look at the Cerutti Mastodon Site. But first, some important context.

The Near Consensus on North American Prehistory

The Clovis Culture is a Native American phenomenon that occurred between about 12 and 10 thousand years ago (most likely between 11,500 and 11,000 uncalibrated radiocarbon years before present). Clovis_Point

The key feature of Clovis is the rather extraordinary “Clovis Point.” There is another, similar looking, point that goes with the Folsom Culture, which is about as old as the Clovis culture, but a bit younger, and there are a couple of other less common named forms. We refer to them all as “fluted points.”

Unlike some other so-called “projectile points” (many of which are knives or spearheads, many perhaps not even mounted in use) fluted points are rarely found in large numbers anywhere, but are represented over a very large region; They are found across the United Sates and Canada, and as far south as Venezuela.

There is almost no evidence suggesting that any humans existed in North America prior to Clovis times, and this has been known for years. Therefore, “Clovis culture” or more broadly, “Paleoindian” culture has long been thought to represent the first humans to come to North America. Since Native Americans physically resemble East Asians (an observation supported and refined by genetic analysis) it has always been assumed that Native Americans came from Asia as Paleoindians, or developed the Paleoindian culture right after arriving in North America. The dates of Clovis sites cluster into such a tight time frame that it makes sense to assume that these folks arrived on an unoccupied continent, spread quickly over a large area, and subsequently differentiated into diverse groups.

The idea of earlier, pre-Clovis, occupation has long been considered by the occasional daring archaeologist, and even the famous African archaeologist, Louis Leakey, suggested that certain finds in the vicinity of modern day San Diego represented much older human occupation. However, North American archaeologists remained firm on the idea that there is no pre-Clovis, and argued strongly and vociferously against the idea. Indeed, any archaeologist who wished to argue for pre-Clovis risked something close to professional censure, others were so sure about Clovis first.

For a very long time it has been at first quietly, and later less quietly, recognized that there are some problems with the Clovis-First hypotheses. First, even though one might expect the early dates for Clovis, if it represented a sudden and rapid colonization of a world with no humans, to be difficult to interpret, it became apparent that the earliest Clovis is in the far East of the continent, with later clovis being farther west. Recent interpretations of the data have suggested that this may not be true, but those interpretations are tenuous. Oddly, pretty solid dating evidence showing east coast Clovis to be earlier was always rejected as unimportant, while a much less clear argument that Clovis out west is early has been quickly and not very critically accepted, presumably because it fits the underlying assumptions of a sudden colonization from Asia.

Fluted points are way more common in the East, east of the Mississippi, in various Mississippi drainage valleys, and along the East Coast. They are relatively sparse in the west, say, on the west side of the Rocky Mountains, and they are very rare in Alaska. So, the distribution of fluted points is exactly the opposite of what one might expect with a simple model of Asians arriving in North America, suddenly becoming Clovis, then spreading from there.

Of the fluted points found in North America, the oldest style, Clovis, is mainly an Eastern phenomenon, with later styles, such as Folsom, are more in the West. If the so-called spatio-temporal boundaries of these styles is correct, and Clovis is older than Folsem, then it is very hard to argue that Clovis is a primary phenomenon that came out of Asia as the first thing people did in North America.

These observations together with the absence of Paleoindian culture in Asia strongly suggests that the actual history of people in North America prior to about 10,000 years ago was a little more complex than the usual textbook version. Indeed, Clovis would make a lot more sense if there was a pre-Clovis culture that did some or much of the initial spreading, followed quickly by the rise of a Clovis Culture among those people, perhaps in the east, which then spread across the continents very quickly. That would have simply been an early example of a phenomenon we see again and again in New World prehistory, where a material phenomenon of some kind, a type of projectile point, or a symbolic image, or something, spreads in what seems like an instant across a vast area.

Beginning mainly in the 1980s, a number of archaeological sites were discovered and presented as pre-Clovis. These are dated using various means. They occur across the US in Pennsylvania, Souoth Carolina, Oregon, Florida, Alaska, and elsewhere. They are also found in South America in Brazil, Chile, and Columbia. Most, perhaps all, of these sites — there are about 16 of them — are very strongly and forcefully argued to be real, and have varying degrees of evidence on them.

Most of the sites date to either just a thousand or two years, or sometime, just centuries, before Clovis and would easily fit into a pre-Clovis model as suggested above. This would go with the idea that somehow, humans arrived in North America, spread out, then popped out Clovis Culture soon after. Some of the sites are much earlier, but as far as I know, all the earliest sites have very questionable artifacts or dating that is not very secure.

I am not certain, but I think most of the North American archaeologists who so forcefully argued against pre-Clovis of any form have either moved off that position, stopped talking, or died off. Now, I believe, most North American archaeologists accept that there is a distinct possibility that there is what I would call a “near-Pre-Clovis.” But, since there are just over one dozen sites across two continents, one must be reserved in assuming this. Such a small number of sites could represent a small number of aberrant if well meaning interpretations of sites that have something wrong with them. I personally have excavated many, many archaeological sites, and I have seen things that can’t be explained. Personally, I think some of the late pre-Clovis sites are good. But, I would not be surprised if an all knowing alien with a time machine landed nearby and proved that I was wrong.

The CM Mastodon Site: Humans in the New World at 130,000 years?

The Cerutti Mastodon site is in San Diego County, California. The site was excavating in the early 1990s by a team from the San Diego Museum of Natural History. If you ever get a chance to visit that museum, do so. It is one of the many museums of Balboa Park, which also includes the famous San Diego Zoo.

3F9FD05F00000578-4447720-image-a-2_1493212011779The finds at this site include a juvenile Mastodon, Mammut Americanum, as well as dire wolf, horse, ground sloth, camel, and mammoth.

The site is dated using Uranium-thorium dating on the mastodon bone, to 130,000 +/- 9,400 years b.p.

A recent analysis of the site, just published in the journal Nature, claims that the bones show evidence of human modification, and that some stones also found on the site show evidence of having been used to modify the bones.

The modification suggested is the smashing of bone to extract marrow, and possibly, to make some flakes or otherwise modify the bone to make tools.

The authors of the paper suggest that there are, as commonly agreed by North American archaeologists, three criteria that a site must meet to be considered a candidate for early pre-Clovis human evidence:

1) archaeological evidence is found in a clearly defined and undisturbed geologic context;

2) age is determined by reliable radiometric dating;

3) multiple lines of evidence from interdisciplinary studies provide consistent results; and

4) unquestionable artefacts are found in primary context

They argue that all of these are met. From the abstract:

The CM site contains spiral-fractured bone and molar fragments, indicating that breakage occured while fresh. Several of these fragments also preserve evidence of percussion. The occurrence and distribution of bone, molar and stone refits suggest that breakage occurred at the site of burial. Five large cobbles (hammerstones and anvils) in the CM bone bed display use-wear and impact marks, and are hydraulically anomalous relative to the low-energy context of the enclosing sandy silt stratum. 230Th/U radiometric analysis of multiple bone specimens using diffusion–adsorption–decay dating models indicates a burial date of 130.7 ± 9.4 thousand years ago. These findings confirm the presence of an unidentified species of Homo at the CM site during the last interglacial period (MIS 5e; early late Pleistocene), indicating that humans with manual dexterity and the experiential knowledge to use hammerstones and anvils processed mastodon limb bones for marrow extraction and/or raw material for tool production. Systematic proboscidean bone reduction, evident at the CM site, fits within a broader pattern of Palaeolithic bone percussion technology in Africa, Eurasia, and North America. The CM site is, to our knowledge, the oldest in situ, well-documented archaeological site in North America and, as such, substantially revises the timing of arrival of Homo into the Americas.

That the site is in a good geological context is apparently beyond question, as far as I know. The “refitting” referred to is where bits and pieces of one thing that was broken apart can be glued back together, showing that since the breaking event not much has moved around, which helps to argue that the site is not too messed up by geological processes. The dating seems good. Everything seems good.

Yay, an early site showing humans in North America way before we ever thought!

But wait, not so fast …

Why this site could be real, and other comments on the early Americas

Archaeologists have a conceptual problem with discontinuity. They don’t believe in it.

Say you are working in a previously unstudied part of the world (there are none, but pretend). You find a site with some pottery on it, and date the site to 1,000 years ago. In the same area, you find several sites, of various dates, from 1,000 years ago to 4,000 years ago, but they are all sites with chipped stone tools on them and no pottery. But then, you finally find another pottery bearing site. The pottery looks different, and the site was fairly deep down, so when you get your dates back from the lab and they are about 4,000 years old, you are not surprised.

And, now, you know that pottery using people lived here from 4,000 years ago to 1,000 years ago, right?

Wrong. It is possible that people showed up here with pottery, and left, leaving behind non-pottery using people, then came back later. Or, people moved here with pottery, or invented or were introduced to pottery, 4,000 years ago, then stopped using it for some reason, then pottery made a return, somehow, more recently. The problem is, most archaeologists will not accept that once something happens, it can unhappen, even though we actually do know of places in the world where pottery was brought there with the first people, then forgotten about or rejected for some reason, later.

So, here’s the idea. During warm periods, like the interglacial of roughly the age of the CM site, and the present, hominins tend to spread. Even the ones that like warmer regions, maybe not even humans, spread around during warm periods, and spread north. So, naturally, some of them get to the New World somehow, and these are them. They don’t even have to be chipped stone tool using humans. They could be bone breakers. They could be bigfoot! They could be anything.

Now, this may seem like a crazy idea, and it almost certainly is. But, the rejection of occupation as early as 130,000 years ago because we have no evidence of anything half that old requires that the new world can be occupied in only one way: something or someone shows up, then they never leave. This is in direct conflict with the known migrations of large mammals, many of which migrated either to the New World from the Old World, or the other way round, several times over that last 5 or more million years, and most of which do not exist in the place they migrated to now.

Why the Old World makes the CM site highly unlikely

I know an archaeologist who once said this. She said, teaching her class, that the discovery of a house structure at about 5,000 years ago (by the way, it might have been the house structure I discovered, which for a time was the oldest one in North America) tells us that by 5,000 years ago, Native Americans had a concept of building a house, like a wigwam, and the technology to do so. I once read an archaeological monograph that suggested that the presence in some 3,000 year old pottery of impressions of woven material show that by that time Native Americans could weave cloth. One textbook refers to the earliest fire in North America (several thousands of years back) indicating that we now knew that by that time, at least, Native Americans had fire and thus could possibly cook their food.

I’ve read and heard North American archaeologists say things like this over and over again. These statements assume that the first proto-Native American people to come to the new world, say as just-pre-Clovis people, must have arrived naked and technology free!

People in the Old World had chipped stone technology, whereby stones were used to break stones in a very systematic (and not too easy to learn) way to produce, ultimately, tools. Our ancestors had this technology before the genus Homo existed. In fact, it may be the case that our ancestors were stone tool chipping bipedal apes for as long before the rise of the genus Homo as after (this remains to be pinned down). Modern humans have existed on this planet for only a fraction of the time that hominins were making chipped stone tools. Until the abrupt and dramatic near perfect elimination of chipped stone technology in recent centuries, chipped stone tool technology was as much a part of human behavior and culture as walking on two legs was.

We know this because of all that Old World archaeology that has been done. Despite the limited understanding of world prehistory by many North American archaeologists, the truth is that a human (even a non-fully modern human) presence in the New World would have chipped stone tools with it.

If a creature was at the CM site with a culture that lacked chipped stone tools, but that used hammer and anvil stones to break up bone, it was an ape, not a hominin. It was Gigantopithecus, or something. Bigfoot! CM is potentially believable as a site if it occurred in a larger time horizon with definitive human evidence. In other words, a bunch of chomped up elephant bones down the way from clear unambiguous human occupation on a landscape with many sites of that date might be acceptable as a human site, but not this. Not just pounded bones with no other cultural manifestations.

Now, I want to add new rules to the ones listed above.

5) The artifacts have to include evidence of proper chipped stone tool technology, as this is a ubiquitous trait of Homo and proto-Homo

6) Among the chipped stone, there must be both flakes and pieces that are flaked, because many natural processes will produce one or the other (usually flaked pieces) without human engagement.

7) The flakes must exhibit many cases of clear striking platforms, the part where the flake is hit to make it fly off the parent rock, and those striking platforms must be mostly below 90 degrees angle, because that is the experimentally established difference between “natural” flakes (including those made by cars running over rocks and rocks falling off cliffs, etc.) and human made proper flakes.

8) If flaked bone is invoked as an artifact type, the flakes must be numerous and have the same low angle of percussion, and there must as noted above, also be stone flakes.

This is the underlying fact that must be understood by people considering the CM site as human. Humans bust up bones, but busted up bones in the absence of any other evidence of human activity does not constitute unquestionable artifactual nature. Ever.

Just to make sure that I was still up to date on bone breakage taphonomy, the study of how to interpret bone breakage, I asked Professor Martha Tappen of the University of Minnesota, a bone taphonomist, for her opinion about the site. She told me, “I would say that the breaks appear to be consistent with human breakage, but quite possibly other causes, too, such as backhoes and perhaps other scenarios involving trampling. Other evidence is needed to support the idea that people reached the new world at this early time.”

What really happened at CM

I spent a certain amount of time living among the elephants of the African Rain Forest. Well, OK, I wan’t actually “living among them” but I was living there doing archaeology and other things, and they were there too. In fact, I studied elephant movement and trial making, and in so doing, observed a lot of places where elephants tromp around.

Some of the elephants we observed in the Ituri (along with the afore mentioned Professor Tappen) which had been killed over the years by Efe hunters (they are the traditional elephant hunters of the region), died on or near regular elephant trails. Once an elephant is all butchered up or scavenged, I assume the living elephants walk around the remains, though in some areas they have been known to play around with the bones of the dead. But eventually, the bones get incorporated with the undergrowth and the sediment, and get trampled by the elephants. The elephants also trample rocks. I saw locations where the elephants walked a lot, including trails and one location where they had dug a cave to obtain sediment that they would eat, where there was so much elephant trampling of stone that most of the stone looked human modified.

CM site has several animals, including some large ones. Something about this site attracted animals that then died, but at one point were alive. This is a very common phenomenon in paleontology, and is not fully understood. It is very likely that the broken up bones and the seemingly modified stones look the way they do because huge multi-ton animals stepped on them repeatedly.

But what if …

I don’t want to rule out CM out of hand. I don’t want to do this because Archaeology is full of stuff that was ruled out by orthodoxy then later found out to be important or real, but data was lost because of the narrow mindedness of the narrow minded. I believe it is appropriate and necessary to reserve a part of our dogma for possibilities, evidence for things that we are pretty sure are not real but that have just enough credibility, just enough of a question, to allow for a later surprise. I would love to see more large mammal sites of the late Pleistocene excavated carefully to see what they look like. A program of exploration for and investigation of sites during and near the Last Glacial Maximum in the Western US is a good idea, and should yield some very interesting paleontological results. If there was some kind of a hominin running around then — which is very unlikely and indeed almost impossible to imagine — but if there was one, it would eventually be bumped into. Meanwhile, think of all the cool extinct animal stuff we would get to learn no matter what the human prehistoric story turns out to be!



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A claim is being made, in a recent issue of Nature Magazine, that humans were active in the vicinity of San Diego well over 100,000 years before archaeologists think humans were even in the New World. Most commentary on this claim dismisses it out of hand, but out of hand rejections are no better than foundationless assertions. Let’s take a closer look at the Cerutti Mastodon Site. But first, some important context.

The Near Consensus on North American Prehistory

The Clovis Culture is a Native American phenomenon that occurred between about 12 and 10 thousand years ago (most likely between 11,500 and 11,000 uncalibrated radiocarbon years before present). Clovis_Point

The key feature of Clovis is the rather extraordinary “Clovis Point.” There is another, similar looking, point that goes with the Folsom Culture, which is about as old as the Clovis culture, but a bit younger, and there are a couple of other less common named forms. We refer to them all as “fluted points.”

Unlike some other so-called “projectile points” (many of which are knives or spearheads, many perhaps not even mounted in use) fluted points are rarely found in large numbers anywhere, but are represented over a very large region; They are found across the United Sates and Canada, and as far south as Venezuela.

There is almost no evidence suggesting that any humans existed in North America prior to Clovis times, and this has been known for years. Therefore, “Clovis culture” or more broadly, “Paleoindian” culture has long been thought to represent the first humans to come to North America. Since Native Americans physically resemble East Asians (an observation supported and refined by genetic analysis) it has always been assumed that Native Americans came from Asia as Paleoindians, or developed the Paleoindian culture right after arriving in North America. The dates of Clovis sites cluster into such a tight time frame that it makes sense to assume that these folks arrived on an unoccupied continent, spread quickly over a large area, and subsequently differentiated into diverse groups.

The idea of earlier, pre-Clovis, occupation has long been considered by the occasional daring archaeologist, and even the famous African archaeologist, Louis Leakey, suggested that certain finds in the vicinity of modern day San Diego represented much older human occupation. However, North American archaeologists remained firm on the idea that there is no pre-Clovis, and argued strongly and vociferously against the idea. Indeed, any archaeologist who wished to argue for pre-Clovis risked something close to professional censure, others were so sure about Clovis first.

For a very long time it has been at first quietly, and later less quietly, recognized that there are some problems with the Clovis-First hypotheses. First, even though one might expect the early dates for Clovis, if it represented a sudden and rapid colonization of a world with no humans, to be difficult to interpret, it became apparent that the earliest Clovis is in the far East of the continent, with later clovis being farther west. Recent interpretations of the data have suggested that this may not be true, but those interpretations are tenuous. Oddly, pretty solid dating evidence showing east coast Clovis to be earlier was always rejected as unimportant, while a much less clear argument that Clovis out west is early has been quickly and not very critically accepted, presumably because it fits the underlying assumptions of a sudden colonization from Asia.

Fluted points are way more common in the East, east of the Mississippi, in various Mississippi drainage valleys, and along the East Coast. They are relatively sparse in the west, say, on the west side of the Rocky Mountains, and they are very rare in Alaska. So, the distribution of fluted points is exactly the opposite of what one might expect with a simple model of Asians arriving in North America, suddenly becoming Clovis, then spreading from there.

Of the fluted points found in North America, the oldest style, Clovis, is mainly an Eastern phenomenon, with later styles, such as Folsom, are more in the West. If the so-called spatio-temporal boundaries of these styles is correct, and Clovis is older than Folsem, then it is very hard to argue that Clovis is a primary phenomenon that came out of Asia as the first thing people did in North America.

These observations together with the absence of Paleoindian culture in Asia strongly suggests that the actual history of people in North America prior to about 10,000 years ago was a little more complex than the usual textbook version. Indeed, Clovis would make a lot more sense if there was a pre-Clovis culture that did some or much of the initial spreading, followed quickly by the rise of a Clovis Culture among those people, perhaps in the east, which then spread across the continents very quickly. That would have simply been an early example of a phenomenon we see again and again in New World prehistory, where a material phenomenon of some kind, a type of projectile point, or a symbolic image, or something, spreads in what seems like an instant across a vast area.

Beginning mainly in the 1980s, a number of archaeological sites were discovered and presented as pre-Clovis. These are dated using various means. They occur across the US in Pennsylvania, Souoth Carolina, Oregon, Florida, Alaska, and elsewhere. They are also found in South America in Brazil, Chile, and Columbia. Most, perhaps all, of these sites — there are about 16 of them — are very strongly and forcefully argued to be real, and have varying degrees of evidence on them.

Most of the sites date to either just a thousand or two years, or sometime, just centuries, before Clovis and would easily fit into a pre-Clovis model as suggested above. This would go with the idea that somehow, humans arrived in North America, spread out, then popped out Clovis Culture soon after. Some of the sites are much earlier, but as far as I know, all the earliest sites have very questionable artifacts or dating that is not very secure.

I am not certain, but I think most of the North American archaeologists who so forcefully argued against pre-Clovis of any form have either moved off that position, stopped talking, or died off. Now, I believe, most North American archaeologists accept that there is a distinct possibility that there is what I would call a “near-Pre-Clovis.” But, since there are just over one dozen sites across two continents, one must be reserved in assuming this. Such a small number of sites could represent a small number of aberrant if well meaning interpretations of sites that have something wrong with them. I personally have excavated many, many archaeological sites, and I have seen things that can’t be explained. Personally, I think some of the late pre-Clovis sites are good. But, I would not be surprised if an all knowing alien with a time machine landed nearby and proved that I was wrong.

The CM Mastodon Site: Humans in the New World at 130,000 years?

The Cerutti Mastodon site is in San Diego County, California. The site was excavating in the early 1990s by a team from the San Diego Museum of Natural History. If you ever get a chance to visit that museum, do so. It is one of the many museums of Balboa Park, which also includes the famous San Diego Zoo.

3F9FD05F00000578-4447720-image-a-2_1493212011779The finds at this site include a juvenile Mastodon, Mammut Americanum, as well as dire wolf, horse, ground sloth, camel, and mammoth.

The site is dated using Uranium-thorium dating on the mastodon bone, to 130,000 +/- 9,400 years b.p.

A recent analysis of the site, just published in the journal Nature, claims that the bones show evidence of human modification, and that some stones also found on the site show evidence of having been used to modify the bones.

The modification suggested is the smashing of bone to extract marrow, and possibly, to make some flakes or otherwise modify the bone to make tools.

The authors of the paper suggest that there are, as commonly agreed by North American archaeologists, three criteria that a site must meet to be considered a candidate for early pre-Clovis human evidence:

1) archaeological evidence is found in a clearly defined and undisturbed geologic context;

2) age is determined by reliable radiometric dating;

3) multiple lines of evidence from interdisciplinary studies provide consistent results; and

4) unquestionable artefacts are found in primary context

They argue that all of these are met. From the abstract:

The CM site contains spiral-fractured bone and molar fragments, indicating that breakage occured while fresh. Several of these fragments also preserve evidence of percussion. The occurrence and distribution of bone, molar and stone refits suggest that breakage occurred at the site of burial. Five large cobbles (hammerstones and anvils) in the CM bone bed display use-wear and impact marks, and are hydraulically anomalous relative to the low-energy context of the enclosing sandy silt stratum. 230Th/U radiometric analysis of multiple bone specimens using diffusion–adsorption–decay dating models indicates a burial date of 130.7 ± 9.4 thousand years ago. These findings confirm the presence of an unidentified species of Homo at the CM site during the last interglacial period (MIS 5e; early late Pleistocene), indicating that humans with manual dexterity and the experiential knowledge to use hammerstones and anvils processed mastodon limb bones for marrow extraction and/or raw material for tool production. Systematic proboscidean bone reduction, evident at the CM site, fits within a broader pattern of Palaeolithic bone percussion technology in Africa, Eurasia, and North America. The CM site is, to our knowledge, the oldest in situ, well-documented archaeological site in North America and, as such, substantially revises the timing of arrival of Homo into the Americas.

That the site is in a good geological context is apparently beyond question, as far as I know. The “refitting” referred to is where bits and pieces of one thing that was broken apart can be glued back together, showing that since the breaking event not much has moved around, which helps to argue that the site is not too messed up by geological processes. The dating seems good. Everything seems good.

Yay, an early site showing humans in North America way before we ever thought!

But wait, not so fast …

Why this site could be real, and other comments on the early Americas

Archaeologists have a conceptual problem with discontinuity. They don’t believe in it.

Say you are working in a previously unstudied part of the world (there are none, but pretend). You find a site with some pottery on it, and date the site to 1,000 years ago. In the same area, you find several sites, of various dates, from 1,000 years ago to 4,000 years ago, but they are all sites with chipped stone tools on them and no pottery. But then, you finally find another pottery bearing site. The pottery looks different, and the site was fairly deep down, so when you get your dates back from the lab and they are about 4,000 years old, you are not surprised.

And, now, you know that pottery using people lived here from 4,000 years ago to 1,000 years ago, right?

Wrong. It is possible that people showed up here with pottery, and left, leaving behind non-pottery using people, then came back later. Or, people moved here with pottery, or invented or were introduced to pottery, 4,000 years ago, then stopped using it for some reason, then pottery made a return, somehow, more recently. The problem is, most archaeologists will not accept that once something happens, it can unhappen, even though we actually do know of places in the world where pottery was brought there with the first people, then forgotten about or rejected for some reason, later.

So, here’s the idea. During warm periods, like the interglacial of roughly the age of the CM site, and the present, hominins tend to spread. Even the ones that like warmer regions, maybe not even humans, spread around during warm periods, and spread north. So, naturally, some of them get to the New World somehow, and these are them. They don’t even have to be chipped stone tool using humans. They could be bone breakers. They could be bigfoot! They could be anything.

Now, this may seem like a crazy idea, and it almost certainly is. But, the rejection of occupation as early as 130,000 years ago because we have no evidence of anything half that old requires that the new world can be occupied in only one way: something or someone shows up, then they never leave. This is in direct conflict with the known migrations of large mammals, many of which migrated either to the New World from the Old World, or the other way round, several times over that last 5 or more million years, and most of which do not exist in the place they migrated to now.

Why the Old World makes the CM site highly unlikely

I know an archaeologist who once said this. She said, teaching her class, that the discovery of a house structure at about 5,000 years ago (by the way, it might have been the house structure I discovered, which for a time was the oldest one in North America) tells us that by 5,000 years ago, Native Americans had a concept of building a house, like a wigwam, and the technology to do so. I once read an archaeological monograph that suggested that the presence in some 3,000 year old pottery of impressions of woven material show that by that time Native Americans could weave cloth. One textbook refers to the earliest fire in North America (several thousands of years back) indicating that we now knew that by that time, at least, Native Americans had fire and thus could possibly cook their food.

I’ve read and heard North American archaeologists say things like this over and over again. These statements assume that the first proto-Native American people to come to the new world, say as just-pre-Clovis people, must have arrived naked and technology free!

People in the Old World had chipped stone technology, whereby stones were used to break stones in a very systematic (and not too easy to learn) way to produce, ultimately, tools. Our ancestors had this technology before the genus Homo existed. In fact, it may be the case that our ancestors were stone tool chipping bipedal apes for as long before the rise of the genus Homo as after (this remains to be pinned down). Modern humans have existed on this planet for only a fraction of the time that hominins were making chipped stone tools. Until the abrupt and dramatic near perfect elimination of chipped stone technology in recent centuries, chipped stone tool technology was as much a part of human behavior and culture as walking on two legs was.

We know this because of all that Old World archaeology that has been done. Despite the limited understanding of world prehistory by many North American archaeologists, the truth is that a human (even a non-fully modern human) presence in the New World would have chipped stone tools with it.

If a creature was at the CM site with a culture that lacked chipped stone tools, but that used hammer and anvil stones to break up bone, it was an ape, not a hominin. It was Gigantopithecus, or something. Bigfoot! CM is potentially believable as a site if it occurred in a larger time horizon with definitive human evidence. In other words, a bunch of chomped up elephant bones down the way from clear unambiguous human occupation on a landscape with many sites of that date might be acceptable as a human site, but not this. Not just pounded bones with no other cultural manifestations.

Now, I want to add new rules to the ones listed above.

5) The artifacts have to include evidence of proper chipped stone tool technology, as this is a ubiquitous trait of Homo and proto-Homo

6) Among the chipped stone, there must be both flakes and pieces that are flaked, because many natural processes will produce one or the other (usually flaked pieces) without human engagement.

7) The flakes must exhibit many cases of clear striking platforms, the part where the flake is hit to make it fly off the parent rock, and those striking platforms must be mostly below 90 degrees angle, because that is the experimentally established difference between “natural” flakes (including those made by cars running over rocks and rocks falling off cliffs, etc.) and human made proper flakes.

8) If flaked bone is invoked as an artifact type, the flakes must be numerous and have the same low angle of percussion, and there must as noted above, also be stone flakes.

This is the underlying fact that must be understood by people considering the CM site as human. Humans bust up bones, but busted up bones in the absence of any other evidence of human activity does not constitute unquestionable artifactual nature. Ever.

Just to make sure that I was still up to date on bone breakage taphonomy, the study of how to interpret bone breakage, I asked Professor Martha Tappen of the University of Minnesota, a bone taphonomist, for her opinion about the site. She told me, “I would say that the breaks appear to be consistent with human breakage, but quite possibly other causes, too, such as backhoes and perhaps other scenarios involving trampling. Other evidence is needed to support the idea that people reached the new world at this early time.”

What really happened at CM

I spent a certain amount of time living among the elephants of the African Rain Forest. Well, OK, I wan’t actually “living among them” but I was living there doing archaeology and other things, and they were there too. In fact, I studied elephant movement and trial making, and in so doing, observed a lot of places where elephants tromp around.

Some of the elephants we observed in the Ituri (along with the afore mentioned Professor Tappen) which had been killed over the years by Efe hunters (they are the traditional elephant hunters of the region), died on or near regular elephant trails. Once an elephant is all butchered up or scavenged, I assume the living elephants walk around the remains, though in some areas they have been known to play around with the bones of the dead. But eventually, the bones get incorporated with the undergrowth and the sediment, and get trampled by the elephants. The elephants also trample rocks. I saw locations where the elephants walked a lot, including trails and one location where they had dug a cave to obtain sediment that they would eat, where there was so much elephant trampling of stone that most of the stone looked human modified.

CM site has several animals, including some large ones. Something about this site attracted animals that then died, but at one point were alive. This is a very common phenomenon in paleontology, and is not fully understood. It is very likely that the broken up bones and the seemingly modified stones look the way they do because huge multi-ton animals stepped on them repeatedly.

But what if …

I don’t want to rule out CM out of hand. I don’t want to do this because Archaeology is full of stuff that was ruled out by orthodoxy then later found out to be important or real, but data was lost because of the narrow mindedness of the narrow minded. I believe it is appropriate and necessary to reserve a part of our dogma for possibilities, evidence for things that we are pretty sure are not real but that have just enough credibility, just enough of a question, to allow for a later surprise. I would love to see more large mammal sites of the late Pleistocene excavated carefully to see what they look like. A program of exploration for and investigation of sites during and near the Last Glacial Maximum in the Western US is a good idea, and should yield some very interesting paleontological results. If there was some kind of a hominin running around then — which is very unlikely and indeed almost impossible to imagine — but if there was one, it would eventually be bumped into. Meanwhile, think of all the cool extinct animal stuff we would get to learn no matter what the human prehistoric story turns out to be!



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Occupational Health News Roundup [The Pump Handle]

At ProPublica, Michael Grabell investigates how U.S. companies take advantage of immigrant workers, focusing on Case Farms poultry plants, which former OSHA chief David Michaels once described as “an outrageously dangerous place to work.” He reports that Case Farms built its business by recruiting some of the world’s most vulnerable immigrants, who often end up working in the kind of dangerous and abusive conditions that few Americans would put up with.

Grabell chronicles the history of Case Farms and how it first began recruiting refugees from Guatemala who were fleeing a brutal civil war in their home country. A former Case Farms human resource manager said of the new Guatemalan workforce in a book cited in the article: “Mexicans will go back home at Christmastime. You’re going to lose them for six weeks. And in the poultry business you can’t afford that. You just can’t do it. But Guatemalans can’t go back home. They’re here as political refugees. If they go back home, they get shot.”

The article begins with the story of worker Osiel López. Grabell writes:

On April 7, 2015, Osiel put on bulky rubber boots and a white hard hat, and trained a pressurized hose on the plant’s stainless steel machines, blasting off the leftover grease, meat and blood.

A Guatemalan immigrant, Osiel was just weeks past his 17th birthday, too young by law to work in a factory. A year earlier, after gang members shot his mother and tried to kidnap his sisters, he left his home, in the mountainous village of Tectitán, and sought asylum in the United States. He got the job at Case Farms with a driver’s license that said his name was Francisco Sepulveda, age 28. The photograph on the ID was of his older brother, who looked nothing like him, but nobody asked any questions.

Osiel sanitized the liver giblet chiller, a tublike contraption that cools chicken innards by cycling them through a near-freezing bath, then looked for a ladder, so that he could turn off the water valve above the machine. As usual, he said, there weren’t enough ladders to go around, so he did as a supervisor had shown him: He climbed up the machine, onto the edge of the tank, and reached for the valve. His foot slipped; the machine automatically kicked on. Its paddles grabbed his left leg, pulling and twisting until it snapped at the knee and rotating it 180 degrees, so that his toes rested on his pelvis. The machine “literally ripped off his left leg,” medical reports said, leaving it hanging by a frayed ligament and a five-inch flap of skin. Osiel was rushed to Mercy Medical Center, where surgeons amputated his lower leg.

Back at the plant, Osiel’s supervisors hurriedly demanded workers’ identification papers. Technically, Osiel worked for Case Farms’ closely affiliated sanitation contractor, and suddenly the bosses seemed to care about immigration status. Within days, Osiel and several others — all underage and undocumented — were fired.

Read the entire investigation, which was co-published with the New Yorker, at ProPublica.

In other news:

Washington Post: Drew Harwell reports that workers in the Chinese factory that produces Ivanka Trump’s fashion line work about 60 hours a week for little more than $62 per week. According to a factory audit, inspectors with the Fair Labor Association found two-dozen violations of international labor standards at the factory, where workers were getting at or below China’s minimum wage. The story comes as Ivanka Trump is positioning herself as an advocate for women in the workplace. Harwell reports: “Fewer than a third of the factory’s workers were offered legally mandated coverage under China’s ‘social insurance’ benefits, including a pension and medical, maternity, unemployment and work-related injury insurance, inspectors found. The factory also did not contribute, as legally required, to a fund designed to help workers afford housing, inspectors said.”

California Healthline (via KQED): Pauline Bartolone reports that advocates are calling on California lawmakers to approve a bill that would require cosmetic companies to disclose ingredients in products used in professional salons. The bill, which already passed the state Assembly health committee, would mandate product labeling that flags hazardous chemicals and require that manufacturers provide ingredient lists on their websites. Right now, federal labeling laws pertain to consumer products, but not to professional products used in salons. Bartolone reports: “Dr. Thu Quach, a researcher at the Cancer Prevention Institute of California, says informing workers of potential risks is especially important given their level of exposure to salon products. Beauty salon workers may absorb chemicals both through their skin and the air they breathe, Quach said. A cosmetologist could apply a chemical-laden treatment to customers 10 times a day, or work in a space where chemicals are recirculating in the air all day, she added.”

Seattle Times: Janet Tu reports that a superior court judge has denied a motion from business trade groups to void the state’s new minimum wage and paid sick leave law, which Washington voters approved last year. In his ruling, the judge said plaintiffs had failed to prove the new laws violated the state constitution. The voter-approved initiative raises the state minimum wage to $13.50 by 2020 and requires paid sick leave for workers. Tu reports: “Judge Sparks wrote in a letter accompanying his ruling that he tries to adhere to the ‘bedrock principle’ that judges should not interfere with laws enacted by the people, whether through referenda or elected officials, unless there is a clear legal necessity.”

Reveal (Center for Investigative Reporting): Jennifer Gollan reports on Trump’s proposal to cut $60 million in grants from the Department of Labor’s Bureau of International Affairs, which addresses child and forced labor abroad. In the budget proposal, Trump suggests that the agency should instead focus on ensuring trade agreements are fair for American workers. Gollan cites a 2014 report on conditions inside Malaysia’s electronics industry as an example of the work the grants support. That report, which revealed highly abusive labor conditions, led to increased scrutiny of the industry and stronger safeguards against trafficking. Gollan writes of the proposed Trump budget cut: “The cuts would hobble one of the country’s key methods for combatting child and forced labor around the globe, and potentially limit the federal government’s ability to help countries comply with labor provisions in 13 free trade agreements. In addition, the cuts could effectively do the opposite of what Trump intends by forcing U.S. companies to increasingly compete with overseas companies that flout worker safeguards and pay meager wages.”

Kim Krisberg is a freelance public health writer living in Austin, Texas, and has been writing about public health for 15 years. Follow me on Twitter — @kkrisberg.



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At ProPublica, Michael Grabell investigates how U.S. companies take advantage of immigrant workers, focusing on Case Farms poultry plants, which former OSHA chief David Michaels once described as “an outrageously dangerous place to work.” He reports that Case Farms built its business by recruiting some of the world’s most vulnerable immigrants, who often end up working in the kind of dangerous and abusive conditions that few Americans would put up with.

Grabell chronicles the history of Case Farms and how it first began recruiting refugees from Guatemala who were fleeing a brutal civil war in their home country. A former Case Farms human resource manager said of the new Guatemalan workforce in a book cited in the article: “Mexicans will go back home at Christmastime. You’re going to lose them for six weeks. And in the poultry business you can’t afford that. You just can’t do it. But Guatemalans can’t go back home. They’re here as political refugees. If they go back home, they get shot.”

The article begins with the story of worker Osiel López. Grabell writes:

On April 7, 2015, Osiel put on bulky rubber boots and a white hard hat, and trained a pressurized hose on the plant’s stainless steel machines, blasting off the leftover grease, meat and blood.

A Guatemalan immigrant, Osiel was just weeks past his 17th birthday, too young by law to work in a factory. A year earlier, after gang members shot his mother and tried to kidnap his sisters, he left his home, in the mountainous village of Tectitán, and sought asylum in the United States. He got the job at Case Farms with a driver’s license that said his name was Francisco Sepulveda, age 28. The photograph on the ID was of his older brother, who looked nothing like him, but nobody asked any questions.

Osiel sanitized the liver giblet chiller, a tublike contraption that cools chicken innards by cycling them through a near-freezing bath, then looked for a ladder, so that he could turn off the water valve above the machine. As usual, he said, there weren’t enough ladders to go around, so he did as a supervisor had shown him: He climbed up the machine, onto the edge of the tank, and reached for the valve. His foot slipped; the machine automatically kicked on. Its paddles grabbed his left leg, pulling and twisting until it snapped at the knee and rotating it 180 degrees, so that his toes rested on his pelvis. The machine “literally ripped off his left leg,” medical reports said, leaving it hanging by a frayed ligament and a five-inch flap of skin. Osiel was rushed to Mercy Medical Center, where surgeons amputated his lower leg.

Back at the plant, Osiel’s supervisors hurriedly demanded workers’ identification papers. Technically, Osiel worked for Case Farms’ closely affiliated sanitation contractor, and suddenly the bosses seemed to care about immigration status. Within days, Osiel and several others — all underage and undocumented — were fired.

Read the entire investigation, which was co-published with the New Yorker, at ProPublica.

In other news:

Washington Post: Drew Harwell reports that workers in the Chinese factory that produces Ivanka Trump’s fashion line work about 60 hours a week for little more than $62 per week. According to a factory audit, inspectors with the Fair Labor Association found two-dozen violations of international labor standards at the factory, where workers were getting at or below China’s minimum wage. The story comes as Ivanka Trump is positioning herself as an advocate for women in the workplace. Harwell reports: “Fewer than a third of the factory’s workers were offered legally mandated coverage under China’s ‘social insurance’ benefits, including a pension and medical, maternity, unemployment and work-related injury insurance, inspectors found. The factory also did not contribute, as legally required, to a fund designed to help workers afford housing, inspectors said.”

California Healthline (via KQED): Pauline Bartolone reports that advocates are calling on California lawmakers to approve a bill that would require cosmetic companies to disclose ingredients in products used in professional salons. The bill, which already passed the state Assembly health committee, would mandate product labeling that flags hazardous chemicals and require that manufacturers provide ingredient lists on their websites. Right now, federal labeling laws pertain to consumer products, but not to professional products used in salons. Bartolone reports: “Dr. Thu Quach, a researcher at the Cancer Prevention Institute of California, says informing workers of potential risks is especially important given their level of exposure to salon products. Beauty salon workers may absorb chemicals both through their skin and the air they breathe, Quach said. A cosmetologist could apply a chemical-laden treatment to customers 10 times a day, or work in a space where chemicals are recirculating in the air all day, she added.”

Seattle Times: Janet Tu reports that a superior court judge has denied a motion from business trade groups to void the state’s new minimum wage and paid sick leave law, which Washington voters approved last year. In his ruling, the judge said plaintiffs had failed to prove the new laws violated the state constitution. The voter-approved initiative raises the state minimum wage to $13.50 by 2020 and requires paid sick leave for workers. Tu reports: “Judge Sparks wrote in a letter accompanying his ruling that he tries to adhere to the ‘bedrock principle’ that judges should not interfere with laws enacted by the people, whether through referenda or elected officials, unless there is a clear legal necessity.”

Reveal (Center for Investigative Reporting): Jennifer Gollan reports on Trump’s proposal to cut $60 million in grants from the Department of Labor’s Bureau of International Affairs, which addresses child and forced labor abroad. In the budget proposal, Trump suggests that the agency should instead focus on ensuring trade agreements are fair for American workers. Gollan cites a 2014 report on conditions inside Malaysia’s electronics industry as an example of the work the grants support. That report, which revealed highly abusive labor conditions, led to increased scrutiny of the industry and stronger safeguards against trafficking. Gollan writes of the proposed Trump budget cut: “The cuts would hobble one of the country’s key methods for combatting child and forced labor around the globe, and potentially limit the federal government’s ability to help countries comply with labor provisions in 13 free trade agreements. In addition, the cuts could effectively do the opposite of what Trump intends by forcing U.S. companies to increasingly compete with overseas companies that flout worker safeguards and pay meager wages.”

Kim Krisberg is a freelance public health writer living in Austin, Texas, and has been writing about public health for 15 years. Follow me on Twitter — @kkrisberg.



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[Stoat]

I’m in a boring meeting, fortunately over Skype, so have time to bring you Antarctic iceberg crack develops fork from Aunty. Nicely, they’ve added Wales for scale; I don’t think Swansea is to scale though.

The pretty banding is SAR interferometry which is cute stuff, though I don’t think the article mentions that. The other picture in the article is also nice, with a clear break in the ice speed at the crack as you’d expect.

Refs

* Don’t Let the Core Fall Out: Nitpicking Earth’s Magnetic Field – BB takes on the Universal Model, featuring Bickmore’s Second Law of Being Open-Minded: A person’s open-mindedness is inversely proportional to how much they lecture everyone else about open-mindedness.
* Gig-Economy Employers Aren’t Free Riding On The Welfare State – Employees Are – Timmy.



from ScienceBlogs http://ift.tt/2qARycp

I’m in a boring meeting, fortunately over Skype, so have time to bring you Antarctic iceberg crack develops fork from Aunty. Nicely, they’ve added Wales for scale; I don’t think Swansea is to scale though.

The pretty banding is SAR interferometry which is cute stuff, though I don’t think the article mentions that. The other picture in the article is also nice, with a clear break in the ice speed at the crack as you’d expect.

Refs

* Don’t Let the Core Fall Out: Nitpicking Earth’s Magnetic Field – BB takes on the Universal Model, featuring Bickmore’s Second Law of Being Open-Minded: A person’s open-mindedness is inversely proportional to how much they lecture everyone else about open-mindedness.
* Gig-Economy Employers Aren’t Free Riding On The Welfare State – Employees Are – Timmy.



from ScienceBlogs http://ift.tt/2qARycp

Job posting: Physical Sciences Librarian and Head of Steacie Science and Engineering Library, York University, Toronto [Confessions of a Science Librarian]

Come work with me! Be my department head!

Here’s the full posting:

Position Rank: Full Time Tenure Stream – Assistant/Associate/Senior Librarian
Discipline/Field: Head of Steacie Science and Engineering Library
Home Faculty: Libraries
Home Department/Area/Division: Steacie Science and Engineering Library
Affiliation/Union: YUFA
Position Start Date: October 1, 2017

Physical Sciences Librarian and Head of Steacie Science and Engineering Library, York University Libraries, York University

York University Libraries seeks an innovative and visionary leader who will inspire the librarians and staff of the Steacie Science and Engineering Library to match the ambition of York’s growing Science, Engineering and Health faculties.

The Steacie Science and Engineering Library has 4.5 full-time librarians and 5.5 full-time support staff and is one of seven libraries in four buildings within the York University Libraries system. It attracts half a million visitors a year and provides specialized resources, research support and information literacy sessions to York’s science, engineering and health programs. Steacie Library takes pride in its extensive information literacy program and successful community outreach events such as its Hackfest, the Ada Lovelace Day Wikipedia Edit-a-thon, Open Access Week and Science Literacy Week.

This is a continuing appointment with an expected designation of Assistant, Associate or Senior Librarian, depending on qualifications. York offers a competitive salary commensurate with qualifications and an exceptional benefits package.

The appointment as head of the Steacie Science and Engineering Library is a five-year term (with possibility of renewal), providing leadership and direction for the department, working collegially with librarians and consultatively with department staff.

Responsibilities include oversight of daily library operations, dealing with staffing levels, mentoring and enabling goal-setting, promoting leadership at different levels, fostering implementation of best practices, and regularly reviewing department structures and procedures to ensure excellence and quality user experience. The department head represents Steacie Library as an advocate of the Libraries; serves as a point of contact for the science and engineering community on campus and externally; and builds partnerships with faculty, university administration and other campus units.

York University Libraries released a new five year strategic plan in 2016 and is currently engaging in a restructuring process. The department head will embrace and implement the plan and lead an ambitious agenda to position Steacie Library as an innovation hub to support the growing Science, Engineering and Health faculties. The candidate will also lead Steacie Library and its staff through this period of change by aligning departmental goals and institutional vision in support of the Libraries’ strategic priorities, and by representing the departmental perspective system-wide.

The successful candidate will act as liaison with the Departments of Chemistry, Physics and Astronomy, and Science and Technology Studies (STS), and the Division of Natural Science, and will build relationships with students, researchers and instructors in these undergraduate and graduate programs. The candidate will support teaching, learning and research; provide information literacy instruction; work with colleagues to provide, promote, manage and evaluate library services, resources and collections; and foster an understanding of the research culture, data needs and publication trends of science and technology researchers. The candidate will also participate in project and committee work for the Libraries and the university, and in external cooperative and professional activities. Some evening and weekend hours may be required.

The successful candidate will have the following qualifications:

  • an ALA-accredited MLIS or equivalent with graduation year of 2007 or later;
  • academic background in the physical sciences or equivalent library professional or work experience in these subject areas;
  • demonstration of a progression of leadership responsibilities and evidence of building effective working relationships with institutional colleagues;
  • demonstrated understanding of information literacy and research competencies in science and STS;
  • demonstrated understanding of the research culture of science and technology, including scholarly communication, publishing trends and corresponding needs of faculty and researchers in the physical sciences;
  • demonstrated expertise with relevant information sources in science and technology, particularly for chemistry, physics and astronomy, including chemical structure searching;
  • understanding of the changing role of academic libraries in higher education and an ability to envision innovative and creative methods of integrating and employing digital technologies;
  • established record of research, publication and professional development;
  • strong public service philosophy and evidence of professional initiative and leadership;
  • strong written and oral communication skills;
  • ability to work collegially with a diverse population of colleagues and patrons; and
  • ability to handle multiple responsibilities and manage priorities.

The position is available from 1 October 2017. All York University positions are subject to budgetary approval.

Librarians at York University have academic status and are members of the York University Faculty Association bargaining unit (http://www.yufa.ca/).

York University is an Affirmative Action (AA) employer and strongly values diversity, including gender and sexual diversity, within its community. The AA program, which applies to Aboriginal people, visible minorities, people with disabilities, and women, can be found at http://ift.tt/1twlbsQ or by calling the AA office at 416-736-5713. All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

People with disabilities and Aboriginal people are priorities in the York University Libraries Affirmative Action plan and are especially encouraged to apply. Consideration will also be given to those who have followed non-traditional career paths or had career interruptions.

The deadline for complete applications is 2 June 2017. Three letters of reference will be requested by 26 June and required by 17 July for candidates who may be interviewed. Interviews will be scheduled in the last two weeks of August.

A letter of application with a current curriculum vitae should be sent to:

Chair, Steacie Librarian Search Committee
York University Libraries
516 Scott Library
4700 Keele St.
Toronto, ON
M3J 1P3
Fax: (416) 736-5451
Email: yulapps@yorku.ca

Posting End Date: June 2, 2017

I’m on the search committee for this posting, so I can really only answer the most basic questions. If anyone would like to speak to someone internally about the York environment, etc., please let me know and I can pass you along to someone. My email is jdupuis at yorku dot ca.



from ScienceBlogs http://ift.tt/2psx4F3

Come work with me! Be my department head!

Here’s the full posting:

Position Rank: Full Time Tenure Stream – Assistant/Associate/Senior Librarian
Discipline/Field: Head of Steacie Science and Engineering Library
Home Faculty: Libraries
Home Department/Area/Division: Steacie Science and Engineering Library
Affiliation/Union: YUFA
Position Start Date: October 1, 2017

Physical Sciences Librarian and Head of Steacie Science and Engineering Library, York University Libraries, York University

York University Libraries seeks an innovative and visionary leader who will inspire the librarians and staff of the Steacie Science and Engineering Library to match the ambition of York’s growing Science, Engineering and Health faculties.

The Steacie Science and Engineering Library has 4.5 full-time librarians and 5.5 full-time support staff and is one of seven libraries in four buildings within the York University Libraries system. It attracts half a million visitors a year and provides specialized resources, research support and information literacy sessions to York’s science, engineering and health programs. Steacie Library takes pride in its extensive information literacy program and successful community outreach events such as its Hackfest, the Ada Lovelace Day Wikipedia Edit-a-thon, Open Access Week and Science Literacy Week.

This is a continuing appointment with an expected designation of Assistant, Associate or Senior Librarian, depending on qualifications. York offers a competitive salary commensurate with qualifications and an exceptional benefits package.

The appointment as head of the Steacie Science and Engineering Library is a five-year term (with possibility of renewal), providing leadership and direction for the department, working collegially with librarians and consultatively with department staff.

Responsibilities include oversight of daily library operations, dealing with staffing levels, mentoring and enabling goal-setting, promoting leadership at different levels, fostering implementation of best practices, and regularly reviewing department structures and procedures to ensure excellence and quality user experience. The department head represents Steacie Library as an advocate of the Libraries; serves as a point of contact for the science and engineering community on campus and externally; and builds partnerships with faculty, university administration and other campus units.

York University Libraries released a new five year strategic plan in 2016 and is currently engaging in a restructuring process. The department head will embrace and implement the plan and lead an ambitious agenda to position Steacie Library as an innovation hub to support the growing Science, Engineering and Health faculties. The candidate will also lead Steacie Library and its staff through this period of change by aligning departmental goals and institutional vision in support of the Libraries’ strategic priorities, and by representing the departmental perspective system-wide.

The successful candidate will act as liaison with the Departments of Chemistry, Physics and Astronomy, and Science and Technology Studies (STS), and the Division of Natural Science, and will build relationships with students, researchers and instructors in these undergraduate and graduate programs. The candidate will support teaching, learning and research; provide information literacy instruction; work with colleagues to provide, promote, manage and evaluate library services, resources and collections; and foster an understanding of the research culture, data needs and publication trends of science and technology researchers. The candidate will also participate in project and committee work for the Libraries and the university, and in external cooperative and professional activities. Some evening and weekend hours may be required.

The successful candidate will have the following qualifications:

  • an ALA-accredited MLIS or equivalent with graduation year of 2007 or later;
  • academic background in the physical sciences or equivalent library professional or work experience in these subject areas;
  • demonstration of a progression of leadership responsibilities and evidence of building effective working relationships with institutional colleagues;
  • demonstrated understanding of information literacy and research competencies in science and STS;
  • demonstrated understanding of the research culture of science and technology, including scholarly communication, publishing trends and corresponding needs of faculty and researchers in the physical sciences;
  • demonstrated expertise with relevant information sources in science and technology, particularly for chemistry, physics and astronomy, including chemical structure searching;
  • understanding of the changing role of academic libraries in higher education and an ability to envision innovative and creative methods of integrating and employing digital technologies;
  • established record of research, publication and professional development;
  • strong public service philosophy and evidence of professional initiative and leadership;
  • strong written and oral communication skills;
  • ability to work collegially with a diverse population of colleagues and patrons; and
  • ability to handle multiple responsibilities and manage priorities.

The position is available from 1 October 2017. All York University positions are subject to budgetary approval.

Librarians at York University have academic status and are members of the York University Faculty Association bargaining unit (http://www.yufa.ca/).

York University is an Affirmative Action (AA) employer and strongly values diversity, including gender and sexual diversity, within its community. The AA program, which applies to Aboriginal people, visible minorities, people with disabilities, and women, can be found at http://ift.tt/1twlbsQ or by calling the AA office at 416-736-5713. All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

People with disabilities and Aboriginal people are priorities in the York University Libraries Affirmative Action plan and are especially encouraged to apply. Consideration will also be given to those who have followed non-traditional career paths or had career interruptions.

The deadline for complete applications is 2 June 2017. Three letters of reference will be requested by 26 June and required by 17 July for candidates who may be interviewed. Interviews will be scheduled in the last two weeks of August.

A letter of application with a current curriculum vitae should be sent to:

Chair, Steacie Librarian Search Committee
York University Libraries
516 Scott Library
4700 Keele St.
Toronto, ON
M3J 1P3
Fax: (416) 736-5451
Email: yulapps@yorku.ca

Posting End Date: June 2, 2017

I’m on the search committee for this posting, so I can really only answer the most basic questions. If anyone would like to speak to someone internally about the York environment, etc., please let me know and I can pass you along to someone. My email is jdupuis at yorku dot ca.



from ScienceBlogs http://ift.tt/2psx4F3

There’s no science behind denying climate change (Synopsis) [Starts With A Bang]

“Whether humans are responsible for the bulk of climate change is going to be left to the scientists, but it’s all of our responsibility to leave this planet in better shape for the future generations than we found it.” -Mike Huckabee

It only makes sense that scientists should debate and argue over the findings in their field. Given all the suites of data available that are relevant to a particular physical phenomenon, how do we put it together in a way that is scientifically robust, allow us to understand and predict what’s happening, and justifiably attribute the causes of observed phenomena? It’s a daunting task, and one that you need science for.

Concentration of CO2 in the atmosphere over the past few hundred thousand years. Image credit: NASA / NOAA.

Concentration of CO2 in the atmosphere over the past few hundred thousand years. Image credit: NASA / NOAA.

So when it comes to global warming, why aren’t the arguments about the temperature and atmospheric concentrations of gases over time? Why are they instead about scientific personalities, profitability, conspiracies and hacked emails? Why, instead, aren’t those opposing the science of human-caused climate change pointing to data and scientific arguments?

The interplay between the atmosphere, clouds, moisture, land processes and the ocean all governs the evolution of Earth's equilibrium temperature. Image credit: Smithsonian Air and Space Museum.

The interplay between the atmosphere, clouds, moisture, land processes and the ocean all governs the evolution of Earth’s equilibrium temperature. Image credit: NASA / Smithsonian Air and Space Museum.

After all, the only thing it would take to overturn anthropogenic climate change was one compelling scientific argument. Learn why, if you value scientific thinking, it’s incompatible with climate change denial.



from ScienceBlogs http://ift.tt/2qumMTl

“Whether humans are responsible for the bulk of climate change is going to be left to the scientists, but it’s all of our responsibility to leave this planet in better shape for the future generations than we found it.” -Mike Huckabee

It only makes sense that scientists should debate and argue over the findings in their field. Given all the suites of data available that are relevant to a particular physical phenomenon, how do we put it together in a way that is scientifically robust, allow us to understand and predict what’s happening, and justifiably attribute the causes of observed phenomena? It’s a daunting task, and one that you need science for.

Concentration of CO2 in the atmosphere over the past few hundred thousand years. Image credit: NASA / NOAA.

Concentration of CO2 in the atmosphere over the past few hundred thousand years. Image credit: NASA / NOAA.

So when it comes to global warming, why aren’t the arguments about the temperature and atmospheric concentrations of gases over time? Why are they instead about scientific personalities, profitability, conspiracies and hacked emails? Why, instead, aren’t those opposing the science of human-caused climate change pointing to data and scientific arguments?

The interplay between the atmosphere, clouds, moisture, land processes and the ocean all governs the evolution of Earth's equilibrium temperature. Image credit: Smithsonian Air and Space Museum.

The interplay between the atmosphere, clouds, moisture, land processes and the ocean all governs the evolution of Earth’s equilibrium temperature. Image credit: NASA / Smithsonian Air and Space Museum.

After all, the only thing it would take to overturn anthropogenic climate change was one compelling scientific argument. Learn why, if you value scientific thinking, it’s incompatible with climate change denial.



from ScienceBlogs http://ift.tt/2qumMTl

adds 2